Masud Husain
Masud Husain is a Professor of Neurology and Cognitive Neuroscience at the University of Oxford. His research examines the neural and neurochemical mechanisms underlying motivation, apathy, and effort-cost decision-making, including the role of dopamine. His published work also focuses on cognitive assessment, memory, and neurobehavioral symptoms in neurological and psychiatric conditions such as Parkinson's disease, Huntington's disease, depression, and dementia.
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Publications
- Dopamine Boosts Motivation for Prosocial Effort in Parkinson's Disease.
- Decision context and neurobehavioural disturbance in Huntington's disease.
- Why Parinaud might deservedly smile.
- Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL.
- Examining effects of effort and reward magnitude on effort-cost decision-making in people with major depressive disorder.
- Transsaccadic working memory in healthy ageing and neurodegenerative disease.
- Brain essay competition winner on artificial general intelligence.
- Computational signatures of exertion and rest underlie moment-to-moment dynamics of subjective perceptions of effort and fatigue.
- A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.
- On the relationships between apathy, depression and anhedonia.
- The social dimension of apathy: evidence for a distinct domain from 11,243 individuals across health and neurocognitive disorders.
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.
- The Relationship Between Sleep, Cognition, and Dementia Risk in People With Focal Epilepsy.
- Evidence from multifeature whole-report in visual short-term memory suggests that not all misbinding is swapping.
- The significance of electrophysiological recordings from the bed nucleus of the stria terminalis in humans.
- Apathy in persons with neurocognitive disorders: Moving the field forward.
- Working Memory Deficits in Hippocampal Amnesia are Associated with Apathy.
- Research agenda to advance anhedonia assessment, understanding and treatment: an ECNP-GALENOS expert meeting report.
- Decision cost hypersensitivity underlies Huntington's disease apathy.
- Increased Sensitivity to Effort and Perception of Effort in People with Schizophrenia.
- Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction.
- A computational approach to understanding effort-based decision-making in depression.
- Impulse Control Disorders and Effort-Based Decision-Making in Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation.
- Performance and validation of a digital memory test across the Alzheimer's disease continuum.
- Listening into hippocampal hyperexcitability in Alzheimer's disease.
- Impact of APOE , Klotho, and sex on cognitive decline with aging.
- Ventromedial prefrontal cortex lesions disrupt learning to reward others.
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.
- Defining brain fog across medical conditions.
- On the responsibilities of intellectuals and the rise of bullshit jobs in universities.
- Clinical research in the UK is failing: universities and NHS trusts need to change.
- Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.
- Active information sampling in health and disease.
- Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer's and Parkinson's disease.
- Responses to 'On the responsibilities of intellectuals and the rise of bullshit jobs in universities'.
- Vascular health has an impact on brain health.
- Goal-directedness deficit in Huntington's disease.
- Self- versus caregiver-reported apathy across neurological disorders.
- General paresis of the insane: a diagnosis not to forget.
- Blunted Reward Prediction Error Encoding Drives Diminished Motivation to Explore in Apathy Associated With Traumatic Brain Injury.
- Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions.
- If patients only knew how bureaucracy obstructs their involvement in research and clinical trials.
- A computational approach to understanding effort-based decision-making in depression.
- Genetic associations of plasma proteomics with dementia subtypes and neuroimaging markers.
- Characterising negative symptoms in schizophrenia: CHANSS study protocol.
- Apathy in older age: why it might signal neurodegeneration.
- Proteomic profiling of Alzheimer's disease and Vascular dementia reveals unique underlying signatures.
- Working Memory Precision and Associative Binding in Mild Cognitive Impairment.
- Apathy and Motivation: Biological Basis and Drug Treatment.
- Effort-based decision making and motivational deficits in stroke patients.
- NHS Health Check attendance is associated with reduced multiorgan disease risk: a matched cohort study in the UK Biobank.
- Was Broca wrong?
- Fatigue predicts quality of life after leucine-rich glioma-inactivated 1-antibody encephalitis.
- Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study.
- Cognition and Memory after Covid-19 in a Large Community Sample.
- A mountain of small things.
- Remote digital cognitive assessment reveals cognitive deficits related to hippocampal atrophy in autoimmune limbic encephalitis: a cross-sectional validation study.
- Cholinergic and noradrenergic aspects of Parkinson's disease.
- Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease.
- The role of the human hippocampus in decision-making under uncertainty.
- LGI1-antibody encephalitis: how to approach this highly treatable dementia mimic in memory and mental health services.
- Feasibility of multiorgan risk prediction with routinely collected diagnostics: a prospective cohort study in the UK Biobank.
- Human ventromedial prefrontal cortex is necessary for prosocial motivation.
- The heterogeneity of Alzheimer's disease.
- The human hippocampus contributes to short-term memory.
- Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.
- Why we need a revolution in clinical research.
- A Cognitive-Behavioral Model of Apathy in Parkinson's Disease.
- Older adults are relatively more susceptible to impulsive social influence than young adults.
- Apathy and Impulsivity Co-Occur in Huntington's Disease.
- Mechanistic insights into allodynia in diabetic peripheral neuropathy.
- Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double-blind placebo-controlled crossover trial.
- Apathy and effort-based decision-making in Alzheimer's disease and subjective cognitive impairment.
- Working memory as a representational template for reinforcement learning.
- Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder.
- Altered reward processing underpins emotional apathy in dementia.
- Mechanisms underlying apathy in frontotemporal dementia.
- Noradrenergic therapies for apathy in Alzheimer's disease?
- 2022 Brain essay competition results.
- Role of serotonin in modulation of decision-making in Parkinson's disease.
- Mechanisms underlying corruption of working memory in Parkinson's disease.
- Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in neurocognitive disorders.
- Screening for Alzheimer's disease: plasma biomarkers and what else?
- Association of Dementia Risk With Focal Epilepsy and Modifiable Cardiovascular Risk Factors.
- The addicted brain: differences between heroin and cocaine?
- Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex.
- An embarrassment of riches? Mechanisms underlying VCP neurodegeneration.
- Clinical assessment of parietal lobe function.
- Effects of cholinesterase inhibition on attention and working memory in Lewy body dementias.
- Effects of COVID-19 on cognition and brain health.
- Subthalamic nucleus shows opposite functional connectivity pattern in Huntington's and Parkinson's disease.
- Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making.
- Dynamic in-flight shifts of working memory resources across saccades.
- Rapid vigilance and episodic memory decrements in COVID-19 survivors.
- Complementary roles of serotonergic and cholinergic systems in decisions about when to act.
- Are there distinct dimensions of apathy? The argument for reappraisal.
- Impact of sleep duration on executive function and brain structure.
- The complex enigma of tau.
- Anhedonia in Neurodegenerative Diseases.
- Smarter adaptive platform clinical trials in neurology.
- Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.
- New developments in frontotemporal dementia.
- Rapid screening for neglect following stroke: A systematic search and European Academy of Neurology recommendations.
- Hyperreactivity to uncertainty is a key feature of subjective cognitive impairment.
- Neural control of hand movement.
- Correction to: Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.
- A new Essay competition for Brain.
- Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study.
- The three deceits of bureaucracy.
- A shared cognitive and neural basis underpinning cognitive apathy and planning in behavioural-variant frontotemporal dementia and Alzheimer's disease.
- Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses.
- Molecular pathology and biomarker of progression in Alzheimer's disease.
- Distinct neural representations for prosocial and self-benefiting effort.
- New mechanistic insights into hereditary spastic paraplegias.
- Risk aversion keeps universities safe and effective. Discuss.
- Preferences for seeking effort or reward information bias the willingness to work.
- Dissociable behavioural signatures of co-existing impulsivity and apathy in decision-making.
- Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants.
- COVID and the brain.