Martin Picard
Martin Picard is a Professor of Behavioral Medicine and Director of the Mitochondrial Psychobiology Group at Columbia University. His research investigates how psychological stress, behavior, and lived experiences influence mitochondrial function, bioenergetics, and aging. His published work includes studies on cell-free mitochondrial DNA as dynamic stress biomarkers, GDF15 signaling in cellular energy sensing, and brain mitochondrial mapping.
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Publications
- Urolithin A Abolishes High Anxiety and Rescues the Associated Mitochondria-Related Transcriptomic Signatures and Synaptic Function.
- Immune Cell Mitochondrial Phenotypes Are Largely Preserved in Mitochondrial Diseases and Do Not Reflect Disease Severity.
- Molecular damage associated with ageing drives inflammation in cardiovascular disease.
- Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions.
- From cancer to Alzheimer's: could a renewed focus on energy transform biomedicine?
- Potential Risks of Blocking GDF15-Based Brain Energy Sensing.
- Saliva cell-free mitochondrial DNA (cf-mtDNA) as a dynamic biomarker of stress and emotion in daily life: Evidence from two independent repeated-measures studies.
- Scalable workflows for high-throughput respirometry.
- Energy constraint on human health.
- Electron microscopy visualization of cell-free mitochondrial DNA-associated vesicular structures in human plasma, serum, and saliva.
- Diurnal dynamics and psychobiological regulation of cell-free mitochondrial and nuclear DNA in human saliva.
- Mapping the GDF15 arm of the integrated stress response in human cells and tissues.
- Mitoception via the Metabokine GDF15 and Human Health.
- Lifetime adversity exposure, mood symptoms, and immune mitochondrial bioenergetics.
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.
- Saliva cell-free mitochondrial DNA (cf-mtDNA) as a dynamic biomarker of stress and emotion in daily life: Evidence from two independent repeated-measures studies.
- The Energetic Cost of Adrenergic Signaling in Primary Human Fibroblasts.
- Saliva cell-free mitochondrial DNA (cf-mtDNA) response during physical and cognitive stress.
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.
- The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress.
- Associations between prenatal distress, mitochondrial health, and gestational age: findings from two pregnancy studies in the USA and Turkey.
- Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.
- Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?
- Balancing the promise and risks of geroscience interventions.
- Recommendations for mitochondria transfer and transplantation nomenclature and characterization.
- Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca 2+ handling across the adult lifespan in men.
- Mitochondrial and Stress-Related Psychobiological Regulation of FGF21 in Humans.
- Blood mitochondrial health markers cf-mtDNA and GDF15 in human aging.
- Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues.
- A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity.
- A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity.
- Biopsychosocial Correlates of Resting and Stress-Reactive Salivary GDF15: Preliminary Findings.
- A human brain map of mitochondrial respiratory capacity and diversity.
- Perceived association of mood and symptom severity in adults with mitochondrial diseases.
- Effects of acute psychological stress on blood cell-free mitochondrial DNA (cf-mtDNA): A crossover experimental study.
- Saliva and Blood Cell-Free mtDNA Reactivity to Acute Psychosocial Stress.
- Mitochondria - the CEO of the cell.
- The Social Lives of Mitochondria: When these energy-giving organelles thrive, so do we.
- Author Correction: A human brain map of mitochondrial respiratory capacity and diversity.
- Mitochondrial health, prenatal distress, and gestational age: investigation of cf-mtDNA and GDF15 in two pregnancy studies from the USA and Turkey.
- Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms.
- Intrinsic health as a foundation for a science of health.
- Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress.
- The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity.
- Mitochondrial Energy Transformation Capacity Influences Brain Activation During Sensory, Affective, and Cognitive Tasks.
- Biopsychosocial correlates of resting and stress-reactive salivary GDF15: preliminary findings.
- Metabolic Effects of Healing Touch During Cervical Cancer Treatment: An Exploratory Analysis.
- The energy resistance principle.
- Mitochondrial and psychosocial stress-related regulation of FGF21 in humans.
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.
- The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model.
- Effects of acute psychological stress on blood cell-free mitochondrial DNA (cf-mtDNA): A crossover experimental study.
- Electron microscopy visualization of cell-free mitochondrial DNA-containing extracellular vesicles in human plasma, serum, and saliva.
- Diurnal dynamics and psychobiological regulation of cell-free mitochondrial and nuclear DNA in human saliva.
- Examining saliva proteomic dynamics in mitochondrial diseases from a perspective of intrinsic health.
- TFAM mislocalization during spermatogenesis.
- Mitochondrial morphology in the mouse adrenal cortex: Influence of chronic psychosocial stress.
- Deep rest: An integrative model of how contemplative practices combat stress and enhance the body's restorative capacity.
- Glucocorticoid and Adrenergic Receptor Distribution Across Human Organs and Tissues: A Map for Stress Transduction.
- Decoding the nature and complexity of extracellular mtDNA: Types and implications for health and disease.
- Hypermetabolism and energetic constraints in mitochondrial disorders.
- Perceived association of mood and symptom severity in adults with mitochondrial diseases.
- A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
- A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity.
- A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity.
- The energetics of cellular life transitions.
- Psychosocial experiences are associated with human brain mitochondrial biology.
- Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.
- Neurodegenerative disorders, metabolic icebergs, and mitohormesis.
- The researcher's guide to selecting biomarkers in mental health studies.
- Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific and individualized regulatory mechanisms.
- The brain-body energy conservation model of aging.
- A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: the MiSBIE study.
- The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress.
- OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases.
- MitoQuicLy: a high-throughput method for quantifying cell-free DNA from human plasma, serum, and saliva.
- Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.
- The prenatal environment and its influence on maternal and child mitochondrial DNA copy number and methylation: A review of the literature.
- Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction.
- MitoQuicLy: A high-throughput method for quantifying cell-free DNA from human plasma, serum, and saliva.
- Taurine deficiency as a driver of aging.
- Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging.
- Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice.
- Spontaneous, long-lasting re-pigmentation of grey hair: an association with psychoemotional stress relief.
- Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children with Sepsis.
- Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis.
- Cellular specificity of mitochondrial and immunometabolic features in major depression.
- Mitochondrial respiratory chain protein co-regulation in the human brain.
- Leukocyte cytokine responses in adult patients with mitochondrial DNA defects.
- The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle.
- Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease.
- Cross-species metabolomic analysis of tau- and DDT-related toxicity.
- Dynamic behavior of cell-free mitochondrial DNA in human saliva.
- Corrigendum to "Dynamic behavior of cell-free mitochondrial DNA in human saliva" [Psychoneuroendocrinology 143 (2022) 105852].
- A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking.
- The energetic cost of allostasis and allostatic load.
- Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop.
- Mitochondrial signal transduction.
- A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations.
- Personality traits are consistently associated with blood mitochondrial DNA copy number estimated from genome sequences in two genetic cohort studies.
- Why Do We Care More About Disease than Health?
- Added sugar intake during pregnancy: Fetal behavior, birth outcomes, and placental DNA methylation.
- Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations.
- Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors.
- Quantitative mapping of human hair greying and reversal in relation to life stress.
- Blood mitochondrial DNA copy number: What are we counting?
- 3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus.
- Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures.
- Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain.
- Blood-based mitochondrial respiratory chain function in major depression.