Glen Jeffery
Glen Jeffery is a professor of neuroscience at University College London. His research focuses on the physiological impacts of light wavelengths on mitochondrial function, aging, and retinal health. His published work examines how long- and short-wavelength light exposure influences visual performance, cellular metabolism, blood glucose levels, and conditions such as age-related macular degeneration.
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Publications
- LED lighting (350-650nm) undermines human visual performance unless supplemented by wider spectra (400-1500nm+) like daylight.
- A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria.
- Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression.
- Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision.
- Light stimulation of mitochondria reduces blood glucose levels.
- Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration.
- Watching the human retina breath in real time and the slowing of mitochondrial respiration with age.
- Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery.
- Exposure to long wavelength light that improves aged mitochondrial function shifts acute cytokine expression in serum and the retina.
- The Effect of Photobiomodulation on the Treatment of Hereditary Mitochondrial Diseases.
- Functional clinical endpoints and their correlations in eyes with AMD with and without subretinal drusenoid deposits-a pilot study.
- The Diagnostic Accuracy of Double-Layer Sign in Detection of Macular Neovascularization Secondary to Central Serous Chorioretinopathy.
- The code of light: do neurons generate light to communicate and repair?
- Near infrared spectroscopy reveals instability in retinal mitochondrial metabolism and haemodynamics with blue light exposure at environmental levels.
- Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain.
- Reindeer eyes seasonally adapt to ozone-blue Arctic twilight by tuning a photonic tapetum lucidum.
- The Role of Neuroglobin in Retinal Hemodynamics and Metabolism: A Real-Time Study.
- Shifting patterns of cellular energy production (adenosine triphosphate) over the day and key timings for the effect of optical manipulation.
- From the Lab to the Field: Translating Applications of Near-Infrared Light from Laboratory to the Field to Improve Honeybee Mitochondrial Function and Hive Health.
- Systemic glucose levels are modulated by specific wavelengths in the solar light spectrum that shift mitochondrial metabolism.
- Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.
- Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration.
- Improved mitochondrial function corrects immunodeficiency and impaired respiration in neonicotinoid exposed bumblebees.
- Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
- The 3D organisation of mitochondria in primate photoreceptors.
- Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function.
- A Pilot Study Evaluating the Effects of 670 nm Photobiomodulation in Healthy Ageing and Age-Related Macular Degeneration.
- Spectral sensitivity of cone vision in the diurnal murid Rhabdomys pumilio .
- Optically Improved Mitochondrial Function Redeems Aged Human Visual Decline.
- Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits.
- Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.
- A hidden footprint: embryological origins of age related macular degeneration.
- Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9- cis -β-Carotene from Dunaliella salina .
- Improving mitochondrial function significantly reduces the rate of age related photoreceptor loss.
- Mitochondrial absorption of short wavelength light drives primate blue retinal cones into glycolysis which may increase their pace of aging.
- Fundamental differences in patterns of retinal ageing between primates and mice.
- A day in the life of mitochondria reveals shifting workloads.
- Photobiomodulation reduces gliosis in the basal ganglia of aged mice.
- The temporal sequence of improved mitochondrial function on the dynamics of respiration, mobility, and cognition in aged Drosophila.
- Does photobiomodulation influence ageing?
- Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline.
- No evidence for loss of short-wavelength sensitive cone photoreceptors in normal ageing of the primate retina.
- Improving mitochondrial function significantly reduces metabolic, visual, motor and cognitive decline in aged Drosophila melanogaster.
- Primate retinal cones express phosphorylated tau associated with neuronal degeneration yet survive in old age.
- Failed Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Repair in Ocular Albinism: Clues to the Role of Melanin in Retinal Pigment Epithelium Pump Function.
- First insights into the expression of VAX2 in humans and its localization in the adult primate retina.
- Amyloid beta deposition and phosphorylated tau accumulation are key features in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.
- Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.
- Iron accumulates in the primate choroid of the eye with aging as revealed with synchrotron X-ray fluorescence microscopy.
- Optical monitoring of retinal respiration in real time: 670 nm light increases the redox state of mitochondria.
- EYS Is a Protein Associated with the Ciliary Axoneme in Rods and Cones.
- Improving Mitochondrial Function Protects Bumblebees from Neonicotinoid Pesticides.
- Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster.
- Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.
- The eyes of the deep diving hooded seal (Cystophora cristata) enhance sensitivity to ultraviolet light.
- Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.
- To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss.
- Ultraviolet vision and avoidance of power lines in birds and mammals.
- Recharging mitochondrial batteries in old eyes. Near infra-red increases ATP.
- Death by color: differential cone loss in the aging mouse retina.
- Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential.
- Laser clearance of drusen deposit in patients with autosomal dominant drusen (p.Arg345Trp in EFEMP1).
- Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.
- Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.
- Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.
- Questioning photostasis.
- Shifting mirrors: adaptive changes in retinal reflections to winter darkness in Arctic reindeer.
- Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function.
- Aged peripheral retinal lesions originating from the ciliary body sweep away the retinal pigmented epithelium.
- Developmental macular disorders: phenotypes and underlying molecular genetic basis.
- Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice.
- Awareness and filling-in of the human blind spot: linking psychophysics with retinal topography.
- Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss.
- Arctic reindeer extend their visual range into the ultraviolet.
- Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina.
- Glatiramer acetate elevates cell production in the mature retinal pigment epithelium.
- Held under arrest: Many mature albino RPE cells display polyploidal features consistent with abnormal cell cycle retention.
- Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery.
- Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages.
- Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells.
- Complement factor h is critical in the maintenance of retinal perfusion.
- Deficits in local and global motion perception arising from abnormal eye movements.
- Developmental dynamics of cone photoreceptors in the eel.
- The fovea regulates symmetrical development of the visual cortex.
- Eel visual pigments revisited: the fate of retinal cones during metamorphosis.
- Survival and remodeling of melanopsin cells during retinal dystrophy.
- Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance.
- Mature retinal pigment epithelium cells are retained in the cell cycle and proliferate in vivo.
- Paradoxical opsin expressing cells in the inner retina that are augmented following retinal degeneration.
- Levels of transient gap junctions between the retinal pigment epithelium and the neuroblastic retina are influenced by catecholamines and correlate with patterns of cell production.
- The ageing photoreceptor.
- The effect of sildenafil citrate (Viagra) on visual sensitivity.
- Differential effect of dopamine on mitosis in early postnatal albino and pigmented rat retinae.
- Viagra slows the visual response to flicker.
- Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin.
- Cell division and cleavage orientation in the developing retina are regulated by L-DOPA.
- Early midline interactions are important in mouse optic chiasm formation but are not critical in man: a significant distinction between man and mouse.
- Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans.
- Regional abnormalities in retinal development are associated with local ocular hypopigmentation.
- Melanopsin (Opn4) positive cells in the cat retina are randomly distributed across the ganglion cell layer.
- Adaptations to an extreme environment: retinal organisation and spectral properties of photoreceptors in Antarctic notothenioid fish.
- Variations in the architecture and development of the vertebrate optic chiasm.
- Optic chiasm formation in humans is independent of foveal development.
- Retinal abnormalities in human albinism translate into a reduction of grey matter in the occipital cortex.
- Protein kinase C immunoreactivity in the pigmented and albino rat retina.
- The orientation and dynamics of cell division within the plane of the developing vertebrate retina.
- Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epithelium.
- Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer.
- A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
- Association of drusen deposition with choroidal intercapillary pillars in the aging human eye.
- Fundus pigment distribution in rhesus monkeys.
- Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice.
- Age-related changes in the dynamics of human albino visual pathways.
- Role of retinal afferents in regulating growth and shape of the lateral geniculate nucleus.
- Correlation between rod photoreceptor numbers and levels of ocular pigmentation.
- Variations in cell density in the ganglion cell layer of the retina as a function of ocular pigmentation.