David Sinclair
David Sinclair is a Professor of Genetics at Harvard Medical School and Co-Chief Editor of the journal Ageing. His work focuses on genetics and longevity science. His published research investigates epigenetic reprogramming, biomarkers of aging and frailty, DNA repair mechanisms, and cellular rejuvenation interventions.
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Publications
- JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.
- Oculomics and AI: The eye as a biomarker for health span.
- Past, present and future perspectives on the science of aging.
- Epigenetic reprogramming for ocular aging and disease: Mechanisms, biomarkers, and the road to the clinic.
- Corrigendum to "Oculomics and AI: The eye as a biomarker for health span" [Asia-Pac J Ophthalmol 15 (1) (2026) 100282].
- Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans.
- The association of frailty with age and lifespan in mice differs by strain and sex.
- A bile acid could explain how calorie restriction slows ageing.
- Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.
- Cellular rejuvenation protects neurons from inflammation-mediated cell death.
- Invigorating discovery and clinical translation of aging biomarkers.
- Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.
- Multiomic clocks to predict phenotypic age in mice.
- Multiomic clocks to predict phenotypic age in mice.
- Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice.
- Emerging strategies, applications and challenges of targeting NAD + in the clinic.
- Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.
- Associations Between Frailty and Cognitive Outcomes Across the Lifespan of Mice.
- DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model.
- DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice.
- The Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy.
- Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming.
- Publisher Correction: Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming.
- Human trials exploring anti-aging medicines.
- TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.
- Response to: The information theory of aging has not been tested.
- Loss of epigenetic information as a cause of mammalian aging.
- A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice.
- Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth.
- Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
- Fertility protection during chemotherapy treatment by boosting the NAD(P) + metabolome.
- Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
- Sex dimorphism and tissue specificity of gene expression changes in aging mice.
- International Gains to Achieving Healthy Longevity.
- Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments.
- Loss of epigenetic information as a cause of mammalian aging.
- Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
- The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors.
- SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance.
- Defining a longevity biotechnology company.
- Chemically induced reprogramming to reverse cellular aging.
- Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation.
- Restricting mealtime ameliorates neurodegeneration.
- Cellular rejuvenation protects neurons from inflammation mediated cell death.
- SIRT2 transgenic over-expression does not impact lifespan in mice.
- Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma.
- The Information Theory of Aging.
- Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults.
- Mitochondrial and metabolic dysfunction in ageing and age-related diseases.
- NAD + in COVID-19 and viral infections.
- Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy.
- Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice.
- Human age reversal: Fact or fiction?
- Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload.
- Novel feature selection methods for construction of accurate epigenetic clocks.
- Sirtuin Evolution at the Dawn of Animal Life.
- Advanced pathological ageing should be represented in the ICD.
- Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
- Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila .
- Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.
- Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes.
- Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice.
- Dynamic stem cell selection safeguards the genomic integrity of the epidermis.
- The economic value of targeting aging.
- NAD + Repletion Rescues Female Fertility during Reproductive Aging.
- The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
- Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers.
- Biomarkers of biological age as predictors of COVID-19 disease severity.
- Why does COVID-19 disproportionately affect older people?
- Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.
- Can artificial intelligence identify effective COVID-19 therapies?
- The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function.
- Age and life expectancy clocks based on machine learning analysis of mouse frailty.
- Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty.
- Reprogramming to recover youthful epigenetic information and restore vision.
- Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
- ARDD 2020: from aging mechanisms to interventions.
- Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung.
- Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.