Bile Acids as Integrators of Nutrient Sensing and Postprandial Metabolism.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms without new empirical human data or systematic review methodology.
PubMed 42629323 · doi:10.1146/annurev-nutr-092724-025135
What was done
This narrative review summarizes literature regarding bile acids as signaling molecules in postprandial metabolism, focusing on receptor pathways (such as farnesoid X receptor and Takeda G protein-coupled receptor), gut microbiota interactions, and host factors influencing bile acid profiles.
What was found
The abstract reports no numerical findings or statistical estimates. It outlines mechanistic pathways by which postprandial circulating bile acids regulate glucose, lipid, and energy metabolism, noting that pool alterations and kinetic dysregulation associate with obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis.
Why it matters
It conceptualizes postprandial bile acid flux as an endocrine integrator linking nutrient intake, gut microbiota diversification, and systemic metabolic homeostasis.
Limits
As a narrative review, it presents no primary clinical data, quantitative pooled analyses, sample sizes, or systematic search methodology in the abstract.