Interplay of Mitochondrial Dynamics, Nutrition, and Vitamins: Evidence From Experimental and Human Studies With Implications for Women's Health.
Level 5 - mechanism / opinion, no new human data
Systematic review synthesizing heterogeneous preclinical (in vitro, animal) and human evidence without meta-analysis of randomized trials.
PubMed 42358203 · doi:10.1155/omcl/8685788
What was done
A systematic review was conducted across electronic databases to evaluate evidence on mitochondrial function, sex-specific differences, and nutritional modulators across in vitro, animal, and human studies. A total of 46 eligible studies examining vitamins, antioxidants, and mitochondrial cofactors were critically synthesized.
What was found
The abstract reports no numerical effect sizes or quantitative results. Across the 46 reviewed studies, vitamins C, D, and E, NAD+ precursors (e.g., nicotinamide riboside), coenzyme Q10, MitoQ, fucoxanthin, and cabergoline were reported to lower oxidative stress, promote mitochondrial biogenesis, enhance electron transport chain activity and ATP generation, and preserve redox balance. The synthesis highlighted that women face increased susceptibility to mitochondrial dysfunction during the menopausal transition.
Why it matters
This review maps the biological mechanisms linking specific micronutrients and mitochondrial integrity to life-stage transitions in women, identifying dietary and supplemental targets for healthy aging.
Limits
The abstract contains no quantitative metrics, meta-analytic pooling, or formal risk-of-bias assessments. Inclusion of in vitro and animal models limits direct clinical translation, and human dosing parameters and hard clinical outcomes remain unquantified.
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