Creatine Supplementation and Acute Sleep Deprivation: A Systematic Review of Cognitive, Psychomotor, and Mood Outcomes.
Level 1 - systematic review of randomized trials
Systematic review of 5 studies
PubMed 42261581 · doi:10.1177/27683605261456529
What was done
Six databases were systematically searched from January 2006 to May 2025 for studies evaluating creatine supplementation's effects on cognitive, psychomotor, and mood outcomes during acute sleep deprivation. Out of 160 records identified, five studies met the inclusion criteria and were synthesized narratively.
What was found
The abstract reports no numerical values, effect sizes, or confidence intervals. The narrative synthesis noted a positive trend favoring creatine supplementation as an intervention for acute sleep deprivation, with effects differing across distinct cognitive domains.
Why it matters
This review compiles the limited literature on whether replenishing cerebral phosphocreatine stores can protect cognitive and psychomotor function during acute sleep loss.
Limits
The literature base is sparse with only five included studies. The abstract provides no quantitative data, participant sample sizes, dosages, or durations of sleep deprivation, precluding definitive conclusions.