Global, regional, and national childhood brain and central nervous system cancer burden: an analysis based on the Global Burden of Disease Study.
Level 3 - non-randomized controlled study
Non-randomized population-based epidemiological modeling study
PubMed 41039581 · doi:10.1186/s41182-025-00810-9
What was done
Data on childhood brain and central nervous system (CNS) cancers from 1990 to 2021 were analyzed using the Global Burden of Disease (GBD) 2021 study. Temporal trends across global, regional, and national levels were assessed using joinpoint regression. A Bayesian age-period-cohort model was employed to project burden trends through 2030.
What was found
No numerical estimates or percentage changes were reported in the abstract. Directionally, from 1990 to 2021, global age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) decreased. Incidence was slightly higher in boys than girls and peaked at ages 0–4 years. Disease burden correlated positively with sociodemographic index. Projections through 2030 indicate continued declines across all burden metrics.
Why it matters
This study tracks multi-decade global trajectories for pediatric CNS tumors, highlighting continuous declines in burden alongside persistent variations by sociodemographic level.
Limits
The abstract provides no raw numbers, rates, or confidence intervals. The analysis relies on GBD modeling and estimates, which are subject to variations in regional cancer registry quality and underreporting in resource-limited areas.
Cited by
- supports Brain cancer is the leading cause of disease-related death in children.