Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic methodology or primary human data
PubMed 40908956 · doi:10.3389/fnagi.2025.1657603
What was done
Narrative review summarizing recent literature on the pathological mechanisms (oxidative stress, inflammation, autophagy, metabolic changes) and emerging therapeutic approaches (pharmacological, genetic, lifestyle) for age-related hearing loss (presbycusis).
What was found
The abstract reports no numerical findings, quantitative effect sizes, or study counts, providing a purely qualitative description of mechanistic pathways and potential intervention strategies.
Why it matters
Synthesizes current mechanistic understanding of presbycusis and highlights potential translational avenues to address hearing loss and associated cognitive decline.
Limits
Narrative review design with no systematic search criteria, quality assessment of included studies, or quantitative synthesis. No primary clinical data or specific sample sizes are reported in the abstract.