Physiopathology of nonalcoholic fatty liver disease: from diet to nutrigenomics.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanisms and dietary factors without systematic review methodology or primary data
PubMed 35920204 · doi:10.1097/MCO.0000000000000859
What was done
This narrative review summarizes the pathophysiological mechanisms of nonalcoholic fatty liver disease (NAFLD). It examines the role of dietary macronutrients (specifically high-fat and high-carbohydrate intake), molecular drivers of de novo lipogenesis and triglyceride synthesis, genetic polymorphisms, epigenetic modifications, and gut dysbiosis in disease onset and dietary management.
What was found
The abstract reports no numerical data, effect estimates, or statistical findings. It highlights that insulin resistance worsened by high-fat and high-carbohydrate diets drives hepatic steatosis through genetically activated pathways, but notes that significant controversies persist regarding the metabolic effects and long-term sustainability of specific dietary regimens.
Why it matters
It outlines how dietary macronutrients and individual nutrigenomic factors interact in hepatic steatosis, framing diet and lifestyle modification as critical mechanistic targets for NAFLD therapy.
Limits
The publication is a narrative overview rather than a systematic review or clinical trial, offering no original human data or quantitative pooling. The abstract lacks specifics on sample populations, study inclusion criteria, or definitive recommendations for specific dietary patterns.