Te Lindert · Handbook of clinical neurology 2018 · narrative review · n=?

Skin temperature, sleep, and vigilance.

Level 5 - mechanism / opinion, no new human data

Narrative book chapter/review synthesizing mechanisms without systematic search methodology

PubMed 30454600 · doi:10.1016/B978-0-444-63912-7.00021-7 · record verified 2026-08-26

What was done

This book chapter reviews the physiological associations linking skin temperature and core body temperature rhythms with sleep propensity and vigilance. It evaluates whether thermoregulation and sleep share common drivers, whether sleep circuits provide efferent signals to thermoregulatory pathways, and whether skin temperature provides afferent input back to sleep-regulating brain regions. It also examines alterations during sleep deprivation and insomnia, and discusses translating laboratory thermal manipulations into real-world applications.

What was found

The abstract reports conceptual and mechanistic frameworks rather than empirical data or numerical statistics. It outlines three parallel regulatory factors: a circadian clock mechanism, a homeostatic hourglass mechanism, and gating factors (sleep-permissive and wake-promoting) that control alertness and sleep induction. It describes laboratory findings indicating that skin temperature manipulations can modify vigilance.

Why it matters

This review highlights skin temperature not just as a passive correlate of circadian phase, but as a potential active afferent modulator of sleep-wake circuitry. This offers a mechanistic foundation for developing non-pharmacological, temperature-based interventions for insomnia and daytime alertness.

Limits

The abstract provides no primary data, systematic search criteria, participant numbers, or quantitative effect sizes. The translational efficacy of applying laboratory thermal manipulations to real-world sleep improvement remains conceptual and unquantified in the abstract.

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